Set in and near the bayou community of Marsh Island, Louisiana, "Moon of the Wolf" starts with the body of a young woman named Ellie being discovered by two locals. Though it appears she was mauled to death by wild dogs, the medical examiner soon determines that she was murdered. The sheriff is faced with the unfortunate task of determining which of his longtime friends or associates in this small, close-knit community are responsible for the brutal killing. His investigation soon leads him into some of the town's little known secrets.